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J Antimicrob Chemother. 2013 Mar;68(3):512-4. doi: 10.1093/jac/dks451. Epub 2012 Dec 2.

High-level expression of cyp51B in azole-resistant clinical Aspergillus fumigatus isolates.

Author information

1
School of Translational Medicine, Manchester Academic Health Science Centre, Faculty of Medicine and Human Sciences, 2nd Floor Education & Research Centre, University Hospital of South Manchester, University of Manchester, Manchester M23 9LT, UK.

Abstract

OBJECTIVES:

Resistance to azole antifungal drugs in Aspergillus fumigatus that is not mediated by target gene mutations is now common in some locations. The aim of this study was to investigate possible new mechanisms of resistance in non-target resistance.

METHODS:

Twelve azole-resistant A. fumigatus isolates previously shown not to carry mutations in cyp51A were tested to determine whether the alternative cyp51B gene was overexpressed.

RESULTS:

Of 12 isolates one showed overinduction of cyp51B after exposure to itraconazole and another showed high constitutive expression of cyp51B.

CONCLUSIONS:

cyp51B overexpression is a possible azole resistance mechanism in A. fumigatus.

PMID:
23208831
DOI:
10.1093/jac/dks451
[Indexed for MEDLINE]

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