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ChemMedChem. 2013 Jan;8(1):43-8. doi: 10.1002/cmdc.201200466. Epub 2012 Dec 3.

From in situ to in vivo: an in situ click-chemistry-derived carbonic anhydrase II imaging agent for positron emission tomography.

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1
Siemens Molecular Imaging Biomarker Research, 6100 Bristol Parkway, Culver City, CA 90230, USA.

Abstract

CA II makes a good PET: Discovering positron emission tomography (PET) probes with high target affinities is challenging. PET probe discovery using in situ click chemistry uses (19) F-bearing fragments as (18) F surrogates. This ensures that the lead hits and PET probes have equivalent chemical or biological characteristics, making PET probe discovery predictable and reliable.

PMID:
23208787
DOI:
10.1002/cmdc.201200466
[Indexed for MEDLINE]
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