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Appl Radiat Isot. 2013 Feb;72:128-32. doi: 10.1016/j.apradiso.2012.10.010. Epub 2012 Oct 23.

An efficient synthesis of dopamine transporter tracer [¹⁸F]FECNT.

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1
Department of Medical Physics, University of Wisconsin-Madison, Madison, 1111 Highland Ave, 1005 WIMR, Madison, WI 53705, United States. dmurali@wisc.edu

Abstract

A simple synthesis of the dopamine transporter ligand [(18)F]FECNT with high radiochemical yield and short synthesis time, suitable for routine production is reported. Reaction of 2β-carbomethoxy-3β-(4-chlorophenyl)nortropane with [(18)F]2-fluoroethyl triflate ([(18)F]FEtOTf) at room temperature for 4 min provided [(18)F]FECNT in 84% decay corrected radiochemical yield. Since [(18)F]FEtOTf was prepared from [(18)F]2-fluoroethyl bromide that was isolated from its starting material, formation of unwanted side products and the amount of expensive precursor used could be greatly reduced. The overall radiochemical yields of [(18)F]FECNT were 40% (n=29) and the total synthesis time was ca. 100 min. The average specific activity of [(18)F]FECNT was 377.4 GBq/μmol (10.2 Ci/μmol).

PMID:
23208243
PMCID:
PMC3540169
DOI:
10.1016/j.apradiso.2012.10.010
[Indexed for MEDLINE]
Free PMC Article
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