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Biosens Bioelectron. 2013 Apr 15;42:362-6. doi: 10.1016/j.bios.2012.10.036. Epub 2012 Oct 17.

Label-free DNA detection using the narrow side of funnel-type etched nanopores.

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Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, PO Box 653, Beer-Sheva 84105, Israel.


A sensitive; simple and label-free method for DNA detection is presented. Irradiated polyethylene terephthalate foils were etched to present conical tracks at a density of approximately 5×10⁷ tracks per cm². Probe DNA was immobilized at the narrow opening of the tracks (2-4 nm diameter). The presence of target DNA resulted in changes in both conductance and rectification ratios in a concentration-dependent manner. DNA concentrations as low as 2 nM could be detected using this simple two-step detection scheme.

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