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J Alzheimers Dis. 2013;34(1):273-9. doi: 10.3233/JAD-121138.

Very old adults with better memory function have higher low-density lipoprotein cholesterol levels and lower triglyceride to high-density lipoprotein cholesterol ratios: KOCOA Project.

Author information

1
Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA. katsumat@ohsu.edu

Abstract

We cross-sectionally examined which lipid profiles are associated with better cognitive function among those aged 80 and older, free of dementia (Clinical Dementia Rating ≤0.5), functionally independent, and community-dwelling. Our cohort consisted of 193 participants from the "Keys to Optimal Cognitive Aging (KOCOA) Project", a prospective cohort study in Okinawa, Japan. Higher low-density lipoprotein cholesterol levels and lower triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratios were associated with higher scores in memory performance after controlling for confounders. Further research is required to clarify the associations among LDL-C levels, TG/HDL-C ratios, and healthy cognitive aging.

PMID:
23207484
PMCID:
PMC3586553
DOI:
10.3233/JAD-121138
[Indexed for MEDLINE]
Free PMC Article

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