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J Int Med Res. 2012;40(5):1708-14.

Association between fibroblast growth factor receptor 4 Gly388Arg polymorphism and ischaemic stroke.

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1
Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China.

Erratum in

  • J Int Med Res. 2014 Oct;42(5):1189.

Retraction in

  • J Int Med Res. 2014 Oct;42(5):1189.

Abstract

OBJECTIVE:

Fibroblast growth factors (FGFs) and their receptors (FGFRs) play important roles in the vascular system. The FGFR4 rs351855 (Gly388Arg) poly morphism has been shown to be a risk factor for many diseases. This case-control study investigated the association between the FGFR4 Gly388Arg polymorphism and susceptibility to ischaemic stroke in the Chinese population.

METHODS:

The FGFR4 Gly388Arg polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in patients with ischaemic stroke and healthy controls.

RESULTS:

Frequencies of genotypes GA and AA, and prevalence of the A allele, were significantly lower in ischaemic stroke patients (n = 952) than in controls (n = 986). Genotype AA and allele A were significantly more frequent in stroke patients with, than in those without, diabetes.

CONCLUSION:

These results suggested that the GA genotype, AA genotype and A allele of FGFR4 Gly388Arg polymorphism are all associated with decreased risk of ischaemic stroke in the Chinese population.

PMID:
23206452
DOI:
10.1177/030006051204000509
[Indexed for MEDLINE]
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