Spontaneous cutaneous papillomatosis in yaks and detection and quantification of bovine papillomavirus-1 and -2

Transbound Emerg Dis. 2013 Oct;60(5):475-80. doi: 10.1111/j.1865-1682.2012.01361.x. Epub 2012 Dec 3.

Abstract

Seven clinical cases of cutaneous papillomatosis in yaks were studied in Arunachal Pradesh, India. Sporadic, single or a chain of multiple varying size warts appeared around the eyes or on the body. Predominant site of warts was around eyes. Histopathologically, these cases were diagnosed as fibropapilloma. It was confirmed by the detection of BPV-1 and BPV-2 or their mixed infection by PCR and sequencing. Quantitative SYBR Green real-time PCR detected comparatively lower viral DNA copy number in cutaneous warts (CWs). Cases of CWs and its causative agent as bovine papillomavirus (BPVs) are reported for the first time in yaks.

Keywords: PCR; bovine papillomavirus; cutaneous warts; fibropapilloma; real-time PCR; yak.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bovine papillomavirus 1 / genetics
  • Bovine papillomavirus 1 / isolation & purification*
  • Cattle
  • Cattle Diseases / diagnosis
  • Cattle Diseases / pathology
  • Cattle Diseases / virology*
  • Coinfection / pathology
  • Coinfection / virology
  • DNA, Viral / analysis
  • DNA, Viral / genetics
  • Deltapapillomavirus / genetics
  • Deltapapillomavirus / isolation & purification*
  • Female
  • Genes, Viral
  • India
  • Male
  • Papilloma / pathology
  • Papilloma / veterinary*
  • Papilloma / virology
  • Phylogeny
  • Polymerase Chain Reaction
  • Real-Time Polymerase Chain Reaction
  • Skin Neoplasms / pathology
  • Skin Neoplasms / veterinary*
  • Skin Neoplasms / virology
  • Warts / pathology
  • Warts / veterinary*
  • Warts / virology

Substances

  • DNA, Viral