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Am J Clin Exp Immunol. 2012;1(2):147-153.

Regulation of Ras signal transduction during T cell development and activation.

Author information

1
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Abstract

T cell receptor-induced activation of the Ras signaling pathway is essential for T cell development, proliferation and differentiation. Given the central role of Ras in T cell biology its activation must be tightly regulated. However, precisely how Ras activation is controlled in T cells is not completely understood. In this review, we provide a summary of the known factors and mechanisms involved in positive and negative regulation of Ras activation in the T cell lineage.

PMID:
23205323
PMCID:
PMC3510699

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