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Sci Rep. 2012;2:910. doi: 10.1038/srep00910. Epub 2012 Nov 30.

Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate.

Author information

1
Univ. de Bordeaux, Institut des Maladies Neurodégénératives , UMR 5293, F-33000 Bordeaux, France.

Abstract

Since age-dependent deposition of Aβ-amyloid has been reported in the Microcebusmurinus, we posited that this animal could as well be a model of age-related synucleinopathy. We characterized the distribution of Aβ-amyloid, α-synuclein and two of its modified forms in the brain of Microcebusmurinus aged from 1.5 to 10 years. Intracytoplasmic α-synuclein aggregates were observed only in aged animals in different brain regions, which were also phospho-Ser129 and nitrated α-synuclein immunoreactive. Age-dependent α-synuclein aggregation occurs spontaneously in mouse lemur primates. Microcebus murinus may provide a model to study age-associated α-synucleinopathy and for testing putative therapeutic interventions for both Alzheimer's and Parkinson's diseases.

PMID:
23205271
PMCID:
PMC3510464
DOI:
10.1038/srep00910
[Indexed for MEDLINE]
Free PMC Article

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