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Rheumatology (Oxford). 2013 Apr;52(4):590-8. doi: 10.1093/rheumatology/kes304. Epub 2012 Nov 30.

Targeting monocytes/macrophages in the treatment of rheumatoid arthritis.

Author information

1
UMR INSERM 1043, CPTP, CHU Purpan, Toulouse, France. jean-luc.davignon@inserm.fr

Abstract

Biotherapies have revolutionized the treatment of RA. However, much work is needed to understand all the mechanisms of these biotherapies, and alternatives are needed to circumvent adverse effects and the high cost of these long-lasting treatments. In this article we outline some of the approaches we have used to target monocytes/macrophages as major components of inflammation and bone homeostasis. We also discuss how anti-TNF-α antibodies target monocytes/macrophages in the complex mechanisms contributing to inhibition of inflammation.

PMID:
23204551
DOI:
10.1093/rheumatology/kes304
[Indexed for MEDLINE]

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