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ChemMedChem. 2013 Apr;8(4):582-6. doi: 10.1002/cmdc.201200461. Epub 2012 Nov 30.

Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1.

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1
Department of Chemistry, Syracuse University, 111 College Place Syracuse, NY 13244, USA.

Abstract

Clearing the way: Glucagon-like peptide-1 (GLP-1) receptor agonists are proving a potent weapon in the treatment of type II diabetes. A new vitamin B(12)-GLP-1 conjugate is investigated and shown to have insulinotropic properties similar to the unmodified peptide. These results are critical to the exploitation of the vitamin B(12) oral uptake pathway for peptide delivery.

PMID:
23203941
PMCID:
PMC3771382
DOI:
10.1002/cmdc.201200461
[Indexed for MEDLINE]
Free PMC Article
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