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Nucleic Acids Res. 2013 Jan;41(Database issue):D233-8. doi: 10.1093/nar/gks1264. Epub 2012 Nov 29.

BSRD: a repository for bacterial small regulatory RNA.

Author information

1
Biology Programme, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.

Abstract

In bacteria, small regulatory non-coding RNAs (sRNAs) are the most abundant class of post-transcriptional regulators. They are involved in diverse processes including quorum sensing, stress response, virulence and carbon metabolism. Recent developments in high-throughput techniques, such as genomic tiling arrays and RNA-Seq, have allowed efficient detection and characterization of bacterial sRNAs. However, a comprehensive repository to host sRNAs and their annotations is not available. Existing databases suffer from a limited number of bacterial species or sRNAs included. In addition, these databases do not have tools to integrate or analyse high-throughput sequencing data. Here, we have developed BSRD (http://kwanlab.bio.cuhk.edu.hk/BSRD), a comprehensive bacterial sRNAs database, as a repository for published bacterial sRNA sequences with annotations and expression profiles. BSRD contains over nine times more experimentally validated sRNAs than any other available databases. BSRD also provides combinatorial regulatory networks of transcription factors and sRNAs with their common targets. We have built and implemented in BSRD a novel RNA-Seq analysis platform, sRNADeep, to characterize sRNAs in large-scale transcriptome sequencing projects. We will update BSRD regularly.

PMID:
23203879
PMCID:
PMC3531160
DOI:
10.1093/nar/gks1264
[Indexed for MEDLINE]
Free PMC Article

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