Format

Send to

Choose Destination
See comment in PubMed Commons below
Viruses. 2012 Nov 1;4(11):2736-53. doi: 10.3390/v4112736.

Dendritic cell apoptosis and the pathogenesis of dengue.

Author information

1
Laboratory of Molecular Virology of the Carlos Chagas Institute, ICC/Fiocruz, Prof. Algacyr Munhoz Mader Street 3775, CIC, Curitiba, Paraná, 81350-010, Brazil. sth_martins@yahoo.com.br

Abstract

Dengue viruses and other members of the Flaviviridae family are emerging human pathogens. Dengue is transmitted to humans by Aedes aegypti female mosquitoes. Following infection through the bite, cells of the hematopoietic lineage, like dendritic cells, are the first targets of dengue virus infection. Dendritic cells (DCs) are key antigen presenting cells, sensing pathogens, processing and presenting the antigens to T lymphocytes, and triggering an adaptive immune response. Infection of DCs by dengue virus may induce apoptosis, impairing their ability to present antigens to T cells, and thereby contributing to dengue pathogenesis. This review focuses on general mechanisms by which dengue virus triggers apoptosis, and possible influence of DC-apoptosis on dengue disease severity.

PMID:
23202502
PMCID:
PMC3509670
DOI:
10.3390/v4112736
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
    Loading ...
    Support Center