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Org Biomol Chem. 2013 Jan 21;11(3):503-8. doi: 10.1039/c2ob26888d. Epub 2012 Nov 30.

A novel ratiometric emission probe for Ca2+ in living cells.

Author information

  • 1Research Center of Environmental Science and Engineering, and School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, P. R. China.

Abstract

A ratiometric fluorescent probe for Ca(2+) based on 1,3,4-oxadiazole derivative has been designed and developed. The probe exhibits a large Stokes shift of 202 nm and a highly selective ratiometric emission response (490/582 nm) to Ca(2+) over other metal cations. Additionally, the probe can readily reveal the changes of intracellular Ca(2+) concentration in living human umbilical vein endothelial cells.

PMID:
23202385
DOI:
10.1039/c2ob26888d
[PubMed - indexed for MEDLINE]
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