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Sensors (Basel). 2012 Oct 8;12(10):13471-9. doi: 10.3390/s121013471.

A novel CD105 determination system based on an ultrasensitive bioelectrochemical strategy with Pt nanoparticles.

Author information

1
Department of Obstetrics & Gynecology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China. zengsuyun2012@126.com

Abstract

CD105 is a well-known tumor metastasis marker and useful for early monitoring of metastasis and cancer relapse. It is important to generate rapid, reliable and precise analytical information regarding CD105 levels. To establish a simple, selective and sensitive detection method, we prepared an immunosensor with novel bioconjugates based on Pt nanoparticles, thionin acetate and antibodies. The proposed immunosensor displayed a broader linear response to CD105, with a working range of 1.3 to 200.0 ng/mL and a detection limit of 0.9 ng/mL under optimal conditions. Moreover, the studied immunosensor exhibited high sensitivity, fast analysis and adequate stability. The proposed methodology could readily be extended to other clinical- or environment-related biospecies.

PMID:
23202005
PMCID:
PMC3545576
DOI:
10.3390/s121013471
[Indexed for MEDLINE]
Free PMC Article

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