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Nutrients. 2012 Nov 6;4(11):1610-21. doi: 10.3390/nu4111610.

Vitamin D interactions with soy isoflavones on bone after menopause: a review.

Author information

1
Department of Nutrition Science, Purdue University, 700 W State St, West Lafayette, IN 47907, USA. cypark@purdue.edu

Abstract

Vitamin D is known to increase Ca absorption in adults. However, the threshold vitamin D status to benefit Ca absorption is lower than the target vitamin D status for higher bone mineral density and lower fracture risk, pointing to another pathway for vitamin D to benefit bone. One possibility is by affecting osteoblast and osteoclasts directly. Vitamin D-related bone metabolism may also be affected by soy isoflavones, which selectively bind to the estrogen receptor β and may reduce bone loss in postmenopausal women. We discuss a possible synergistic effect of soy isoflavones and vitamin D on bone by affecting osteoblast and osteoclast formation and activity in postmenopausal women.

PMID:
23201836
PMCID:
PMC3509509
DOI:
10.3390/nu4111610
[Indexed for MEDLINE]
Free PMC Article

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