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Nature. 1990 Mar 29;344(6265):410-4.

A sodium-potassium switch in the formation of four-stranded G4-DNA.

Author information

1
Department of Cellular and Development Biology, Harvard University, Cambridge, Massachusetts 02138.

Abstract

Single-stranded complex guanine-rich DNA sequences from chromosomal telomeres and elsewhere can associate to form stable parallel four-stranded structures termed G4-DNA by a process that is anomalously dependent on the particular alkali metal cation that is present. The anomaly, which is not found in the formation of G4-DNA by oligonucleotides containing short, single runs of three or more guanines, is caused by potassium cations excessively stabilizing fold-back intermediate structures, or pathway by-products.

PMID:
2320109
DOI:
10.1038/344410a0
[Indexed for MEDLINE]

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