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J Ethnopharmacol. 2013 Jan 30;145(2):573-80. doi: 10.1016/j.jep.2012.11.032. Epub 2012 Nov 28.

Shikonin ameliorates cerulein-induced acute pancreatitis in mice.

Author information

1
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Shikonin, a highly liposoluble naphthoquinone pigment isolated from the traditional medical herbs Lithospermum erythrorhizon (LE), was considered to exhibit an anti-inflammatory property. While the potential of shikonin to ameliorate acute pancreatitis (AP) is unknown. Our aim was to investigate the effects of shikonin in a murine model of cerulein-induced pancreatitis.

MATERIALS AND METHODS:

AP was induced in mice by six intraperitoneal injection of cerulein (50 μg/kg) at hourly intervals. Vehicle or shikonin (50 mg/kg) was pretreated 2 h before the first cerulein injection. After 6 h, 9 h and 12 h of the first cerulein injection, the severity of acute pancreatitis was assessed by biochemistry, myeloperoxidase activity, histological grading, proinflammatory cytokines levels and nuclear factor kappa B (NF-κB) activity.

RESULTS:

Shikonin administration significantly reduced serum amylase and lipase activities, pancreatic histological scores, TNF-α, IL-1β, IL-6 levels, MPO activity and NF-κB activity.

CONCLUSION:

Taken together, these results suggest that shikonin might protect against experimental pancreatitis by reducing release of inflammatory cytokines via inhibition of NF-κB activity. The therapeutic role of shikonin in AP needs further investigation.

PMID:
23201088
DOI:
10.1016/j.jep.2012.11.032
[Indexed for MEDLINE]

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