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Crit Rev Oncol Hematol. 2013 Jun;86(3):222-31. doi: 10.1016/j.critrevonc.2012.10.007. Epub 2012 Nov 29.

The history of adoption of hepatic resection for metastatic colorectal cancer: 1984-95.

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1
Department of Surgery, Aintree University Hospitals NHS Foundation Trust, Liverpool, UK.

Abstract

BACKGROUND:

Liver resection for metastatic colorectal cancer became established without randomized trials. Proponents of surgical resection point out 5-year survival approaching 50% whilst critics question how much of the apparent effect is due to patient selection.

METHOD:

A 2006 systematic review of reported outcomes provided the starting point for citation analysis followed by thematic analysis of the texts of the most cited papers.

RESULTS:

54 reports from 1988 to 2002 cited 709 unique publications a total of 1714 times. The 15 most cited papers were explored in detail, and showed clear examples of duplicate reporting and overlapping data sets. Textual analysis revealed proposals for a randomized controlled trial, but this was argued to be unethical by others, and no trial was undertaken.

CONCLUSIONS:

This critical review reveals how the case for this surgery was made, and examines the arguments that influenced acceptance and adoption of this surgery.

[Indexed for MEDLINE]

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