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Curr Opin Cell Biol. 2013 Feb;25(1):72-7. doi: 10.1016/j.ceb.2012.10.016. Epub 2012 Nov 27.

Building a centriole.

Author information

1
Department of Biological Sciences, University of Toledo, Toledo, OH 43606, USA. Tomer.AvidorReiss@utoledo.edu

Abstract

Centrioles are the key foundation of centrosomes and cilia, yet a molecular understanding of how they form has only recently begun to emerge. Building a fully functional centriole that can form a centrosome and cilium requires two cell cycles. Centriole building starts with procentriole nucleation, a process that is coordinated by the conserved proteins Plk4/Zyg-1, and Asterless/Cep152. Subsequently, Sas-6, a conserved procentriole protein, self-assembles to provide nine-fold symmetry to the centriole scaffold. The procentriole then continues to elongate into a centriole, a process controlled by Sas-4/CPAP and CP110. Then, centrioles recruit Sas-4-mediated pre-assembled centrosomal complexes from the cytoplasm to form the pericentriolar material (PCM). Finally, CP110 and its interacting proteins are involved in controlling the timing of centriole templating of the cilium.

PMID:
23199753
PMCID:
PMC3578074
DOI:
10.1016/j.ceb.2012.10.016
[Indexed for MEDLINE]
Free PMC Article

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