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Expert Rev Anti Infect Ther. 2012 Oct;10(10):1109-15. doi: 10.1586/eri.12.108.

Rediscovering high technology from the past: thoracic surgery is back on track for multidrug-resistant tuberculosis.

Author information

1
Department of Infectious Diseases, Galliera Hospital, Genoa, Italy.

Abstract

The global emergence of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB represents a core challenge for global tuberculosis control. MDR-TB and extensively drug-resistant TB are more difficult to treat and have a worse outcome compared with drug-susceptible disease. Surgery has proved to improve treatment success in MDR-TB patients. This study was designed to assess the impact of surgery in a cohort of MDR-TB patients. The authors evaluate one of the largest cohorts treated by a single center, demonstrating that specialized thoracic surgery centers may achieve excellent results with a low rate of complications after surgery, and proposing an effective model of teamwork based on pulmonologists and surgeons. A review of the evidence supporting the role of surgery in addition to chemotherapy to improve treatment outcomes in difficult-to-treat cases of TB is also performed.

PMID:
23199397
DOI:
10.1586/eri.12.108

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