Format

Send to

Choose Destination
See comment in PubMed Commons below
J Ophthalmic Vis Res. 2009 Oct;4(4):228-31.

Slow versus Rapid Fluorescein Injection in Angiographic Studies for Retinal Vascular Disorders.

Author information

1
Guilan University of Medical Sciences, Rasht, Iran.

Abstract

PURPOSE:

To compare the incidence of adverse reactions following rapid versus slow fluorescein injection for fundus angiography.

METHODS:

This randomized controlled trial was performed on 500 patients with retinal vascular disorders. Subjects with central serous retinopathy, age-related macular degeneration and retinal pigment epithelial changes were excluded. Pregnancy, asthma, allergic diseases and previous history of reactions to fluorescein were other exclusion criteria. Patients were randomly divided into two equal groups who received slow infusion of dye (over 15-25 seconds) versus the usual rapid injection (in 5-8 seconds), and were compared for adverse effects.

RESULTS:

Overall, 47 (9.4%) patients including 34 (13.6%) subjects in the rapid group and 13 (5.2%) cases in the slow group developed adverse reactions (P=0.001, relative risk=2.6). All adverse reactions were categorized as mild; no instance of moderate or severe reactions was observed. There was a lower incidence of nausea and vomiting with slow infusion of fluorescein (P=0.02), however no statistically significant difference was observed in the frequency of vertigo and vasovagal reactions between the study groups.

CONCLUSION:

Slow fluorescein injection during fundus angiography, instead of the usual rapid application, can be an effective way to reduce the incidence of nausea and vomiting in patients whose first phase of angiography is of little diagnostic importance.

KEYWORDS:

Fluorescein Angiography; Nausea; Slow Infusion; Vomiting

PMID:
23198078
PMCID:
PMC3498860
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center