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Acta Neurochir (Wien). 2013 Feb;155(2):211-6. doi: 10.1007/s00701-012-1566-z. Epub 2012 Nov 30.

Incidence of growth and rupture of unruptured intracranial aneurysms followed by serial MRA.

Author information

1
Department of Neurosurgery, Iseikai Hospital, 6-2-25, Sugawara Higashi Yodogawa-ku, Osaka City, Osaka, 533-0022, Japan. BYX05641@nifty.ne.jp

Abstract

BACKGROUND:

The natural history, including growth and rupture, of unruptured intracranial aneurysms (UIAs) remains unknown. Here, we present the results of serial magnetic resonance angiography (MRA) follow-up study in 111 patients with 136 UIAs.

METHOD:

A total of 111 patients with 136 UIAs were followed annually over the past 12 years, using 1.5-Tesla MRA. Follow-up was ended when UIAs were treated surgically, or the patients died of subarachnoid hemorrhage or other causes. Various factors influencing aneurysm rupture or growth were examined statistically.

RESULTS:

Aneurysm rupture and growth occurred in six and 13 of the 111 patients, respectively. Annual rupture rate was 1.8 % per year and annual growth rate was 3.9 % per year. Aneurysm size was the sole factor influencing rupture(H.R. 1.214, 95 % CI, 1.078-1.368) and multiplicity was the sole factor influencing aneurysm growth (H.R. 5.174, 95 % CI 1.81-14.80).

CONCLUSIONS:

Serial MRA study showed that the incidence of UIA growth was twice as high as that of UIA rupture. As four patients showed aneurysm rupture or growth within 1 year, further investigations are necessary to determine the optimum interval of radiological investigation and to identify which UIAs grow or rupture within a short time.

PMID:
23196925
DOI:
10.1007/s00701-012-1566-z
[Indexed for MEDLINE]
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