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Nat Cell Biol. 2012 Dec;14(12):1248-9. doi: 10.1038/ncb2642.

MyomiRs-133a/b turn off the heat.

Author information

1
Max Planck Institute for Neurological Research, Gleueler Street 50a, 50931 Köln, Germany.

Abstract

Brown adipose tissue is intensively researched owing to its role in regulating energy and glucose homeostasis. Its differentiation is controlled through adrenergic-dependent regulation of the transcriptional co-regulator Prdm16. Adrenergic stimulation inhibits expression of miR-133a/b in a Mef2c-dependent manner to abrogate post-transcriptional silencing of Prdm16.

PMID:
23196844
DOI:
10.1038/ncb2642
[Indexed for MEDLINE]

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