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Biochim Biophys Acta. 2013 Jul;1828(7):1541-9. doi: 10.1016/j.bbamem.2012.11.019. Epub 2012 Nov 27.

The α2δ subunits of voltage-gated calcium channels.

Author information

1
Department of Neuroscience, Physiology and Pharmacology, University College London, UK. a.dolphin@ucl.ac.uk

Abstract

Voltage-gated calcium channels consist of the main pore-forming α1 subunit, together, except in the case of the T-type channels, with β and α2δ and sometimes γ subunits, which are collectively termed auxiliary or accessory subunits. This review will concentrate on the properties and role of the α2δ subunits of these channels. These proteins are largely extracellular, membrane-associated proteins which influence the trafficking, localization, and biophysical properties of the channels. This article is part of a Special Issue entitled: Calcium channels.

PMID:
23196350
DOI:
10.1016/j.bbamem.2012.11.019
[Indexed for MEDLINE]
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