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J Mol Diagn. 2013 Jan;15(1):3-16. doi: 10.1016/j.jmoldx.2012.06.008. Epub 2012 Nov 27.

Identification of evidence-based biospecimen quality-control tools: a report of the International Society for Biological and Environmental Repositories (ISBER) Biospecimen Science Working Group.

Author information

1
Integrated Biobank of Luxembourg, Luxembourg. fay.betsou@ibbl.lu

Abstract

Control of biospecimen quality that is linked to processing is one of the goals of biospecimen science. Consensus is lacking, however, regarding optimal sample quality-control (QC) tools (ie, markers and assays). The aim of this review was to identify QC tools, both for fluid and solid-tissue samples, based on a comprehensive and critical literature review. The most readily applicable tools are those with a known threshold for the preanalytical variation and a known reference range for the QC analyte. Only a few meaningful markers were identified that meet these criteria, such as CD40L for assessing serum exposure at high temperatures and VEGF for assessing serum freeze-thawing. To fully assess biospecimen quality, multiple QC markers are needed. Here we present the most promising biospecimen QC tools that were identified.

PMID:
23195791
PMCID:
PMC5707193
DOI:
10.1016/j.jmoldx.2012.06.008
[Indexed for MEDLINE]
Free PMC Article

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