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Curr Opin Cell Biol. 2013 Feb;25(1):30-8. doi: 10.1016/j.ceb.2012.10.009. Epub 2012 Nov 27.

Post-translational modification and regulation of actin.

Author information

1
Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. jonathan.terman@utsouthwestern.edu

Abstract

Many of the best-studied actin regulatory proteins use non-covalent means to modulate the properties of actin. Yet, actin is also susceptible to covalent modifications of its amino acids. Recent work is increasingly revealing that actin processing and its covalent modifications regulate important cellular events. In addition, numerous pathogens express enzymes that specifically use actin as a substrate to regulate their hosts' cells. Actin post-translational alterations have been linked to different normal and disease processes and the effects associated with metabolic and environmental stressors. Herein, we highlight specific co-translational and post-translational modifications of actin and discuss the current understanding of the role that these modifications play in regulating actin.

PMID:
23195437
PMCID:
PMC3578039
DOI:
10.1016/j.ceb.2012.10.009
[Indexed for MEDLINE]
Free PMC Article

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