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Ugeskr Laeger. 2012 Nov 26;174(48):3007-10.

[No evidence of malicious effect of NSAID treatment on bone healing].

[Article in Danish]

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An√¶stesiologisk Afdeling, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 K√łbenhavn NV, Denmark.


The use of NSAIDs for postoperative pain management following orthopaedic surgery or during conservative treatment of fractures is controversial. Experimental animal models suggest NSAIDs inhibit bone healing. In a review of the literature, there was no clinical evidence to support categorical discard of NSAID for postoperative pain relief in uncomplicated cases. However, NSAID should be considered a potentiel risk factor of impaired bone healing and avoided in patients with a high risk of pseudoarthrosis. Recommended daily doses should be respected and duration of treatment should be limited.

[Indexed for MEDLINE]

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