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Int Psychogeriatr. 2013 Jul;25(7):1199-201. doi: 10.1017/S1041610212002037. Epub 2012 Nov 30.

A case in which mirtazapine reduced auditory hallucinations in a patient with Parkinson disease.

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  • 1Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan.


A 48-year-old woman with Parkinson disease (PD) suffered from auditory hallucinations (AH). We had treated her with a reduction in antiparkinsonian agents and the use of atypical antipsychotic agents. However, her symptoms did not improve, and her extrapyramidal symptoms (EPS) worsened. To lessen her depressive symptoms, treatment with a new-generation antidepressant, mirtazapine (MRZ), was commenced. The patient's AH gradually decreased with no worsening of EPS, and the AH disappeared 4 weeks after the commencement of treatment with MRZ. The present case suggests the effectiveness of MRZ for the treatment of refractory AHs in patients with PD.

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