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Am J Clin Nutr. 2013 Jan;97(1):66-71. doi: 10.3945/ajcn.112.048991. Epub 2012 Nov 28.

Omega-6 fatty acids and risk of heart failure in the Physicians' Health Study.

Author information

1
Brigham and Women's Hospital, Boston, MA 02120, USA.

Abstract

BACKGROUND:

Although 1 in 5 adults will develop heart failure (HF) in their lifetime, data on the effect of plasma omega-6 (n-3) PUFAs on risk of HF are currently sparse.

OBJECTIVES:

We investigated whether plasma phospholipid omega-6 concentrations are associated with risk of HF in US male physicians. In a secondary analysis, we evaluated whether such an association differs between HF with and without previous myocardial infarction (MI).

DESIGN:

With the use of a nested case-control design, this ancillary study comprised 788 cases and 788 matched controls from the Physicians' Health Study. Plasma omega-6 PUFAs were measured by using gas chromatography.

RESULTS:

The mean age of subjects was 58.7 y with a mean follow-up time of 17.1 y. We did not show any evidence of a statistically significant relation between total omega-6 PUFAs and HF [OR (95% CI): 1.00; 0.85 (0.63, 1.14); 0.84 (0.63, 1.13); and 0.87 (0.63, 1.20) across consecutive quartiles of omega-6 PUFAs; P-linear trend = 0.39]. Results were similar for HF with and without previous MI.

CONCLUSION:

Our data showed no significant association between total plasma omega-6 PUFAs and risk of developing HF.

PMID:
23193008
PMCID:
PMC3522140
DOI:
10.3945/ajcn.112.048991
[Indexed for MEDLINE]
Free PMC Article

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