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Psychopharmacology (Berl). 2013 Apr;226(3):541-50. doi: 10.1007/s00213-012-2925-4. Epub 2012 Nov 29.

Interaction between the mGlu receptors 5 antagonist, MPEP, and amphetamine on memory and motor functions in mice.

Author information

1
Dipartimento di Biologia e Biotecnologie "C. Darwin", Università degli Studi di Roma "La Sapienza", Rome, Italy.

Abstract

RATIONALE:

Metabotropic glutamate mGlu receptors 5 (mGluR5) receptors are abundant in corticolimbic circuitry where they modulate glutamate and dopamine signal transduction.

OBJECTIVES:

In this study, we explored the hypothesis that mGluR5 antagonist, (2-methyl-6-(phenylethynyl)pyridine hydrochloride) (MPEP), facilitates dopamine-dependent effects on memory and motor functions.

METHODS:

To this aim, we examined the effects of different doses (from 0 to 24 mg/kg) of the mGluR5 antagonist, MPEP, on the modulation of amphetamine-dependent behaviors, namely passive avoidance, locomotor activity, and rotation behavior in intact and dopamine-depleted CD1 male mice.

RESULTS:

We demonstrated that a low dose (3 mg/kg) of MPEP, which is void of behavioral effects on its own, facilitates amphetamine-induced effects independently on the behavior measured both in naïve and in dopamine-lesioned mice; this synergistic effect is lost when higher doses of MPEP are used.

CONCLUSION:

The results are discussed in terms of possible balance between dopamine and glutamate activity in regulating the proper fine tuning of information processing.

PMID:
23192313
DOI:
10.1007/s00213-012-2925-4
[Indexed for MEDLINE]

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