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Immunology. 2013 Mar;138(3):183-9. doi: 10.1111/imm.12046.

The aryl hydrocarbon receptor: a molecular pathway for the environmental control of the immune response.

Author information

1
Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. fquintana@rics.bwh.harvard.edu

Abstract

Environmental factors have significant effects on the development of autoimmune diseases. The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) is controlled by endogenous and environmental small molecules. Hence, AHR provides a molecular pathway by which endogenous and environmental signals can influence the immune response and the development of autoimmune diseases. AHR also provides a target for therapeutic intervention in immune-mediated disorders. In this review, we discuss the role of AHR in the regulation of T-cell differentiation and autoimmunity.

PMID:
23190340
PMCID:
PMC3573271
DOI:
10.1111/imm.12046
[Indexed for MEDLINE]
Free PMC Article

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