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Annu Rev Med. 2013;64:357-66. doi: 10.1146/annurev-med-050311-163340. Epub 2012 Nov 26.

Podocyte biology and pathogenesis of kidney disease.

Author information

1
Department of Medicine, Rush University Medical Center, Chicago, Illinois 60612, USA. jochen_reiser@rush.edu

Abstract

Proteinuric chronic kidney disease (CKD), once a rare affliction believed to be mainly caused by genetic mutations, has become a global pandemic that severely diminishes the quality of life for millions. Despite the changing face of CKD, treatment options and resources remain woefully antiquated and have failed to arrest or reverse the effects of kidney-related diseases. Histological and genetic data strongly implicate one promising target: the podocyte. Podocytes are terminally differentiated cells of the kidney glomerulus that are essential for the integrity of the kidney filter. Their function is primarily based on their intricate structure, which includes foot processes. Loss of these actin-driven membrane extensions is tightly connected to the presence of protein in the urine, podocyte loss, development of CKD, and ultimately renal failure.

PMID:
23190150
PMCID:
PMC3736800
DOI:
10.1146/annurev-med-050311-163340
[Indexed for MEDLINE]
Free PMC Article
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