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Nat Rev Neurosci. 2013 Jan;14(1):69-75. doi: 10.1038/nrn3393. Epub 2012 Nov 28.

The circadian clock: a framework linking metabolism, epigenetics and neuronal function.

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Department of Biological Chemistry, Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, California 92697, USA.


The circadian clock machinery is responsible for biological timekeeping on a systemic level. The central clock system controls peripheral clocks through a number of output cues that synchronize the system as a whole. There is growing evidence that changing cellular metabolic states have important effects on circadian rhythms and can thereby influence neuronal function and disease. Epigenetic control has also been implicated in the modulation of biological timekeeping, and cellular metabolism and epigenetic state seem to be closely linked. We discuss the idea that cellular metabolic state and epigenetic mechanisms might work through the circadian clock to regulate neuronal function and influence disease states.

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