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Cell Cycle. 2012 Dec 15;11(24):4530-5. doi: 10.4161/cc.22820. Epub 2012 Nov 27.

The "Sharp" blade against HIF-mediated metastasis.

Author information

1
Medical Research Council, Toxicology Unit, Leicester University, Leicester, UK.

Abstract

Hypoxia-inducible factors (HIFs) control cellular adaptation to oxygen deprivation. Cancer cells engage HIFs to sustain their growth in adverse conditions, thus promoting a cellular reprograming that includes metabolism, proliferation, survival and mobility. HIFs overexpression in human cancer biopsies correlates with high metastasis and mortality. A recent report has elucidated a novel mechanism for HIFs regulation in triple-negative breast cancer. Specifically, the basic helix-loop-helix (bHLH), Sharp-1, serves HIF1α to the proteasome and promotes its O 2-indendpendet degradation, counteracting HIF-mediated metastasis. These findings shed light on how HIFs are manipulated during cancer pathogenesis.

PMID:
23187809
PMCID:
PMC3562297
DOI:
10.4161/cc.22820
[Indexed for MEDLINE]
Free PMC Article
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