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Chest. 2013 Apr;143(4):1009-1017. doi: 10.1378/chest.12-1684.

Systemic inflammatory pattern of patients with community-acquired pneumonia with and without COPD.

Author information

1
Department of Pulmonary Rehabilitation, Ospedale Villa Pineta, University of Modena and Reggio Emilia, Modena, Italy.
2
Servicio de Neumología, Hospital Universitario y politecnico La Fe, CIBERES, Valencia, Spain.
3
Pneumology Department, Clinic Institute of Thorax, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
4
Pneumology Department, Clinic Institute of Thorax, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain. Electronic address: ATORRES@clinic.ub.es.

Abstract

BACKGROUND:

Several clinical studies have evaluated the role of COPD in patients with community acquired pneumonia (CAP). We investigated the systemic inflammatory response of patients with CAP (CAP 1 COPD) and patients without associated COPD (CAP only).

METHODS:

Clinical, microbiologic, and immunologic data were collected from 367 prospective patients on admission to hospital during a 3-year period. Comparative analyses were performed between patients with CAP 1 COPD (n 5 117) and those with CAP only (n 5 250) and between patients with and without domiciliary use of inhaled corticosteroids (ICSs) and oral corticosteroids.

RESULTS:

Detailed characteristics of clinical severity and prognosis (mortality on hospitalization and at 30 and 90 days) were similar between the CAP 1 COPD and CAP-only groups. The readmission rate and the frequency of previous pneumonia were higher in the group of patients with CAP 1 COPD. On day 1 (admission to hospital), patients with CAP 1 COPD had significantly lower serum levels of tumor necrosis factor- a , IL-1, and IL-6 compared with the CAP-only group; levels of the remaining inflammatory biomarkers (C-reactive protein, procalcitonin, IL-8, and IL-10) were similar at days 1 and 3. The exclusion of patients with domiciliary use of ICS and oral corticosteroids confirmed lower levels of TNF- a on day 1 in patients with CAP 1 COPD. Finally, lower levels of IL-6 were found only among those patients with COPD who were currently using ICS.

CONCLUSIONS:

Our prospective study demonstrates a different, disease-specific, early inflammatory pattern between patients with CAP with and without associated COPD. These findings are not completely corticosteroid mediated.

PMID:
23187314
DOI:
10.1378/chest.12-1684
[Indexed for MEDLINE]

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