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J Infect Dis. 2013 Feb 15;207(4):656-60. doi: 10.1093/infdis/jis725. Epub 2012 Nov 27.

NF135.C10: a new Plasmodium falciparum clone for controlled human malaria infections.

Author information

1
Department of Medical Microbiology, Radboud University Nijmegen Medical Center, the Netherlands.

Abstract

We established a new field clone of Plasmodium falciparum for use in controlled human malaria infections and vaccine studies to complement the current small portfolio of P. falciparum strains, primarily based on NF54. The Cambodian clone NF135.C10 consistently produced gametocytes and generated substantial numbers of sporozoites in Anopheles mosquitoes and diverged from NF54 parasites by genetic markers. In a controlled human malaria infection trial, 3 of 5 volunteers challenged by mosquitoes infected with NF135.C10 and 4 of 5 challenged with NF54 developed parasitemia as detected with microscopy. The 2 strains induced similar clinical signs and symptoms as well as cellular immunological responses.

CLINICAL TRIALS REGISTRATION:

NCT01002833.

PMID:
23186785
PMCID:
PMC3549599
DOI:
10.1093/infdis/jis725
[Indexed for MEDLINE]
Free PMC Article

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