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Aust Dent J. 2012 Dec;57(4):404-8. doi: 10.1111/adj.12006. Epub 2012 Oct 23.

Casein phosphopeptide-amorphous calcium phosphate: a remineralizing agent of enamel.

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Department of Pedodontics, Saveetha Dental College, Chennai, India.


The pathogenesis of enamel caries involves a succession of demineralization and remineralization activities. The net effect can result in lesion consolidation when the redeposited minerals improve the resistance of the surface to the extent that the usual level of cariogenic activity cannot cause mineral dissolution. Since it has been established that the caries process is a continuum, albeit one that is interrupted numerous times daily, it is therefore possible to intervene at any stage with a therapeutic product or an intervention methodology. Incorporation of remineralizing treatments into routine dental care programmes will have a strong impact on the public health aspects of caries control. A recent advancement in the phenomenon of remineralization is the casein phosphopeptides. These casein phosphopeptides localize the amorphous calcium phosphate and are proved to be anticariogenic. This review discusses the mechanism of remineralization by casein phosphopeptide-amorphous calcium phosphate and its incorporation into various products.

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