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Ther Adv Endocrinol Metab. 2012 Oct;3(5):141-62. doi: 10.1177/2042018812458697.

Interventions for the metabolic syndrome in schizophrenia: a review.

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CSI Lab, Department of Psychosis Studies, Institute of Psychiatry, KCL, De Crespigny Park, PO63, Denmark Hill, London SE5 8AF, UK.


The metabolic syndrome (MetS) is an increasingly prevalent condition in people with schizophrenia. It remains highly prevalent in the general population in developed countries, but recently health promotion campaigns and greater awareness of the high associated mortality rates have resulted in improvements in the rates of cardiovascular risk factors. This is not the case for people with schizophrenia who continue to have more than twice the rates of MetS and significantly higher mortality rates than the general population. Various behavioural and pharmacological interventions have been used to improve conditions that are linked to MetS, mainly smoking and obesity. This review aims to provide an update of the latest knowledge about the behavioural, pharmacological and other interventions that might help to combat this life-threatening problem in people with schizophrenia.


Antipsychotic-induced weight gain; cardiovascular risk factors; diabetes; metabolic syndrome; obesity; physical exercise; physical health intervention; schizophrenia; smoking cessation; weight reduction/management

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