Format

Send to

Choose Destination
Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20479-84. doi: 10.1073/pnas.1211705109. Epub 2012 Nov 26.

Circadian regulation of olfaction and an evolutionarily conserved, nontranscriptional marker in Caenorhabditis elegans.

Author information

1
Department of Molecular Chronobiology, Faculty of Mathematics and Natural Science, University of Groningen, 9474 AG Groningen, The Netherlands. maria.olmedo@med-uni.muenchen.de

Abstract

Circadian clocks provide a temporal structure to processes from gene expression to behavior in organisms from all phyla. Most clocks are synchronized to the environment by alternations of light and dark. However, many organisms experience only muted daily environmental cycles due to their lightless spatial niches (e.g., caves or soil). This has led to speculation that they may dispense with the daily clock. However, recent reports contradict this notion, showing various behavioral and molecular rhythms in Caenorhabditis elegans and in blind cave fish. Based on the ecology of nematodes, we applied low-amplitude temperature cycles to synchronize populations of animals through development. This entrainment regime reveals rhythms on multiple levels: in olfactory cued behavior, in RNA and protein abundance, and in the oxidation state of a broadly conserved peroxiredoxin protein. Our work links the nematode clock with that of other clock model systems; it also emphasizes the importance of daily rhythms in sensory functions that are likely to impact on organism fitness and population structure.

PMID:
23185015
PMCID:
PMC3528576
DOI:
10.1073/pnas.1211705109
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center