Format

Send to

Choose Destination
Adv Healthc Mater. 2012 Jul;1(4):432-6. doi: 10.1002/adhm.201200046. Epub 2012 May 2.

Microfluidic cell sorter (μFCS) for on-chip capture and analysis of single cells.

Author information

1
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114, USA.

Abstract

A low-cost and rapid microfluidic cell sorter (μFCS) for circulating tumor cell (CTC) detection, culture and analyses is developed. Based on size separation and molecular characterization, μFCS efficiently enriches CTCs from unprocessed whole blood, allows on-chip culture and molecular profiling, and provides cell retrieval for subsequent analyses. The potential clinical application of the technology is demonstrated by capturing and genetically analyzing CTCs in tumor-bearing mice.

PMID:
23184773
PMCID:
PMC3508764
DOI:
10.1002/adhm.201200046
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center