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Adv Healthc Mater. 2012 May;1(3):316-20. doi: 10.1002/adhm.201100033. Epub 2012 Apr 2.

Cascaded photoinduced drug delivery to cells from multifunctional core-shell mesoporous silica.

Author information

1
Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany.

Abstract

Different bioactive molecules are released into living cells from lipid-covered mesoporous silica nanoparticles. The release is triggered by light, as the particles feature covalently attached photosensitizers as membrane-opening agents. It is demonstrated that the particles achieve endosomal escape and that they release their cargo into the cytosol.

PMID:
23184746
DOI:
10.1002/adhm.201100033
[Indexed for MEDLINE]
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