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FEBS Lett. 1990 Mar 12;262(1):82-6.

Identification of the Arg-Gly-Asp sequence in laminin A chain as a latent cell-binding site being exposed in fragment P1.

Author information

1
Max-Planck-Institut für Biochemie, Martinsried, FRG.

Abstract

A single RGD-containing sequence present within an epidermal growth factor-like repeat of the short arms of laminin is shown by peptide inhibition to block integrin receptors recognizing a latent cell-binding site of laminin. Based on proteolysis data it is proposed that masking occurs by folding of the globular domain IVa over the cell-binding site in the adjacent rod-like structures of laminin A chain.

PMID:
2318314
DOI:
10.1016/0014-5793(90)80159-g
[Indexed for MEDLINE]
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