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Semin Cell Dev Biol. 2013 Mar;24(3):200-9. doi: 10.1016/j.semcdb.2012.11.002. Epub 2012 Nov 24.

Developing a sense of taste.

Author information

1
Ecole Normale Superieure, Institut de Biologie, 75005 Paris, France. marika.kapsimali@ens.fr

Abstract

Taste buds are found in a distributed array on the tongue surface, and are innervated by cranial nerves that convey taste information to the brain. For nearly a century, taste buds were thought to be induced by nerves late in embryonic development. However, this view has shifted dramatically. A host of studies now indicate that taste bud development is initiated and proceeds via processes that are nerve-independent, occur long before birth, and governed by cellular and molecular mechanisms intrinsic to the developing tongue. Here we review the state of our understanding of the molecular and cellular regulation of taste bud development, incorporating important new data obtained through the use of two powerful genetic systems, mouse and zebrafish.

PMID:
23182899
PMCID:
PMC3604069
DOI:
10.1016/j.semcdb.2012.11.002
[Indexed for MEDLINE]
Free PMC Article

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