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Biol Psychol. 2013 Feb;92(2):216-9. doi: 10.1016/j.biopsycho.2012.11.013. Epub 2012 Nov 24.

Reduced alpha and exaggerated theta power during the resting-state EEG in fragile X syndrome.

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Leiden University, Institute of Psychology, The Netherlands.


This study characterizes the resting-state EEG in males with fragile X syndrome to reveal abnormalities in oscillatory brain dynamics. Analyses of the eyes-closed EEG epochs showed that the resting-state EEG in FXS can be characterized by elevated relative theta power (4-8 Hz) and reduced relative upper-alpha power (10-12 Hz). Although preliminary, these findings suggest that the well-documented imbalance in excitatory/inhibitory cortical circuit activity in FXS can be revealed the level of oscillatory behavior at the scalp. A next step for future studies is linking the EEG resting-state indices to cognitive and behavioral measures.

[Indexed for MEDLINE]

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