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Trends Plant Sci. 2013 Mar;18(3):125-32. doi: 10.1016/j.tplants.2012.10.004. Epub 2012 Nov 20.

ABI4: versatile activator and repressor.

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Molecular Plant Physiology, Institute of Environmental Biology, Utrecht University, Utrecht, The Netherlands.


The ABSCISIC ACID INSENSITIVE4 (ABI4) gene was discovered to be an abscisic acid (ABA) signaling responsive transcription factor active during seed germination. The evolutionary history of the ABI4 gene supports its role as an ABA signaling intermediate in land plants. Investigating the ABI4 protein-cis element interaction supports the proposal that ABI4 binding to its known CE1 cis-element competes with transcription factor binding to the overlapping G-Box element. Recent publications report on ABI4 as a regulatory factor in diverse processes. In developing seedlings, ABI4 mediates sugar signaling, lipid breakdown, and plastid-to-nucleus signaling. Moreover, ABI4 is a regulator of rosette growth, redox signaling, cell wall metabolism and the effect of nitrate on lateral root development.

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