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Front Neurol. 2012 Nov 19;3:161. doi: 10.3389/fneur.2012.00161. eCollection 2012.

Metabolic syndrome and migraine.

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Department of Neurology, Jefferson Headache Center, Thomas Jefferson University Philadelphia, PA, USA.


Migraine and metabolic syndrome are highly prevalent and costly conditions. The two conditions coexist, but it is unclear what relationship may exist between the two processes. Metabolic syndrome involves a number of findings, including insulin resistance, systemic hypertension, obesity, a proinflammatory state, and a prothrombotic state. Only one study addresses migraine in metabolic syndrome, finding significant differences in the presentation of metabolic syndrome in migraineurs. However, controversy exists regarding the contribution of each individual risk factor to migraine pathogenesis and prevalence. It is unclear what treatment implications, if any, exist as a result of the concomitant diagnosis of migraine and metabolic syndrome. The cornerstone of migraine and metabolic syndrome treatments is prevention, relying heavily on diet modification, sleep hygiene, medication use, and exercise.


hyperlipidemia; hypertension; inflammatory state; insulin resistance; metabolic syndrome; migraine; obesity; prothrombotic state

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