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Ophthalmologe. 2012 Nov;109(11):1073-6. doi: 10.1007/s00347-012-2642-8.

[Preservatives from the perspective of glaucoma surgery].

[Article in German]

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Universitätsaugenklinik, Otto von Guericke Universität, Leipziger Str. 44, 39120, Magdeburg, Deutschland.


Trabeculectomy is still the gold standard in the surgical treatment of glaucoma patients. Development of a bleb is the primary goal of this procedure and the conjunctival status is therefore decisive. Only a good functioning bleb renders good intraocular pressure (IOP) control. Scar tissue formation leads to bleb failure which is quite common despite the use of antiproliferative agents, such as mitomycin C and 5 fluoruracil. Wound healing is important and is influenced and impaired by the chronic use of topical antiglaucoma drugs. Therefore, complete abstinence is recommended from 4-6 weeks prior to a planned trabeculectomy; however, it seems mandatory to completely abolish preservatives such as drops containing benzalkonium chloride to enhance trabeculectomy success rates.

[Indexed for MEDLINE]

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