Format

Send to

Choose Destination
See comment in PubMed Commons below
Arch Gynecol Obstet. 2013 Apr;287(4):803-7. doi: 10.1007/s00404-012-2632-8. Epub 2012 Nov 20.

Analysis of sperm telomere length in men with idiopathic infertility.

Author information

1
Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi 110029, India.

Abstract

PURPOSE:

Telomeres are multifunctional nucleoprotein domains with hexanucleotide tandem repeat (5' TTAGGG 3') sequences, which cap the chromosome ends. However, the role of telomere and its length in sperm with regard to fertility remains unknown.

METHODS:

In this pilot study, we analyzed 32 idiopathic infertile men and 25 controls for sperm telomere length by quantitative polymerase chain reaction (Q-PCR), and correlated it with sperm DNA fragmentation index (DFI) and reactive oxygen species (ROS) levels.

RESULTS:

The relative sperm mean telomere length (T/S) of infertile men was found to be significantly lower (p < 0.005) when compared to controls (0.674 ± 0.028 vs. 0.699 ± 0.030). None of the sperm parameters such as sperm count, forward motility, morphology, ROS, and DFI were found to correlate with the sperm telomere length.

CONCLUSION:

Shorter telomeres in sperm may be one of the causative factors responsible for male infertility, but further detailed studies are needed to confirm these findings.

PMID:
23179801
DOI:
10.1007/s00404-012-2632-8
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center