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J Nat Med. 2013 Jul;67(3):619-25. doi: 10.1007/s11418-012-0723-2. Epub 2012 Nov 23.

Saw palmetto ethanol extract inhibits adipocyte differentiation.

Author information

1
Department of Biological Sciences, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA.

Abstract

The fruits of saw palmetto have been used for the treatment of a variety of urinary and reproductive system problems. In this study we investigated whether the fruit extracts affect in vitro adipogenesis. Saw palmetto ethanol extract inhibited the lipid droplet accumulation by induction media in a dose-dependent manner, and it also attenuated the protein expressions of C-EBPα and PPARγ. Phosphorylation of Erk1/2 and Akt1 were also decreased by saw palmetto ethanol extract. This report suggests that saw palmetto extracts selectively affect the adipocyte differentiation through the modulation of several key factors that play a critical role during adipogenesis.

PMID:
23179316
DOI:
10.1007/s11418-012-0723-2
[Indexed for MEDLINE]

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